{"id":50430,"date":"2026-11-10T02:35:15","date_gmt":"2026-11-10T01:35:15","guid":{"rendered":"https:\/\/www.mixtv1.com\/index.php\/2026\/11\/10\/how-to-deal-with-wearing-off-phenomenon-in-ms-treatment\/"},"modified":"2026-11-10T02:35:15","modified_gmt":"2026-11-10T01:35:15","slug":"how-to-deal-with-wearing-off-phenomenon-in-ms-treatment","status":"publish","type":"post","link":"https:\/\/www.mixtv1.com\/index.php\/2026\/11\/10\/how-to-deal-with-wearing-off-phenomenon-in-ms-treatment\/","title":{"rendered":"How to Deal With \u2018Wearing-Off\u2019 Phenomenon in MS Treatment"},"content":{"rendered":"<p>Why Does the Wearing-Off Phenomenon Happen?<\/p>\n<p>Experts don\u2019t know the answer to this yet. And there may be more than one reason. Because not all DMTs work in the same way, the reason for the wearing-off phenomenon may depend on the type of drug you\u2019re taking.<\/p>\n<p>Natalizumab, for example, prevents certain immune cells from getting into your central nervous system and causing damaging inflammation, says Dr. Gratch. But it blocks these cells for only about 8 weeks at a time before its effects begin to diminish. For that reason, patients typically receive infusions of natalizumab every 4 to 6 weeks. When spaced much further apart, you risk what\u2019s called a rebound effect, in which your MS becomes active again, leading to symptoms and new lesions.<\/p>\n<p>\u201cIt\u2019s very well known and established that if you go about 8 to 12 weeks without getting natalizumab or switching [to another] DMT,<\/p>\n<p> <a class=\"echo_read_more\" href=\"https:\/\/www.everydayhealth.com\/neurological-disorders\/wearing-off-phenomenon-in-multiple-sclerosis-care\/\" target=\"_blank\">\u00a0\u00bb\u00a0More Info >>><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why Does the Wearing-Off Phenomenon Happen? Experts don\u2019t know the answer to this yet. And there may be more than one reason. Because not all DMTs work in the same way, the reason for the wearing-off phenomenon may depend on the type of drug you\u2019re taking. Natalizumab, for example, prevents certain immune cells from getting<\/p>\n","protected":false},"author":55,"featured_media":50431,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"categories":[97],"tags":[36,3290],"class_list":["post-50430","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-mixtv","tag-neurological-disorders"],"_links":{"self":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts\/50430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/comments?post=50430"}],"version-history":[{"count":0,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts\/50430\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/media\/50431"}],"wp:attachment":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/media?parent=50430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/categories?post=50430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/tags?post=50430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}