{"id":51266,"date":"2026-11-13T02:35:19","date_gmt":"2026-11-13T01:35:19","guid":{"rendered":"https:\/\/www.mixtv1.com\/index.php\/2026\/11\/13\/measuring-success-how-mek-inhibitors-work-on-unresectable-plexiform-neurofibromas-in-neurofibromatosis-type-1-nf1\/"},"modified":"2026-11-13T02:35:19","modified_gmt":"2026-11-13T01:35:19","slug":"measuring-success-how-mek-inhibitors-work-on-unresectable-plexiform-neurofibromas-in-neurofibromatosis-type-1-nf1","status":"publish","type":"post","link":"https:\/\/www.mixtv1.com\/index.php\/2026\/11\/13\/measuring-success-how-mek-inhibitors-work-on-unresectable-plexiform-neurofibromas-in-neurofibromatosis-type-1-nf1\/","title":{"rendered":"Measuring Success: How MEK Inhibitors Work on Unresectable Plexiform Neurofibromas in Neurofibromatosis Type 1 (NF1)"},"content":{"rendered":"

How Doctors Measure Success<\/p>\n

Doctors judge whether a MEK inhibitor is working in two main ways: by measuring the tumor on MRI scans<\/a> and by asking how you\u2019re feeling, including your pain and how well you can move and function, says Giglio.<\/p>\n

Tumor Volume<\/p>\n

Plexiform neurofibromas are measured with volumetric MRI, which calculates a tumor\u2019s full three-dimensional size. In clinical trials, a tumor was considered responsive to treatment if it shrank by at least 20 percent and the change held up on a second scan two to six months later.<\/p>\n

Because tumors take months to start shrinking, an MRI about every six months is reasonable, though there\u2019s no hard-and-fast rule, says Brown. \u201cIf we scan too early and don\u2019t see a change yet, patients can get discouraged,\u201d she says.<\/p>\n

Function and Quality of Life<\/p>\n

In clinical trials, people rate their worst tumor pain on a scale of 0 to 10 and fill out questionnaires on how much pain gets in the way of daily life and on their overall quality of life.<\/p>\n

\u00a0\u00bb\u00a0More Info >>><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

How Doctors Measure Success Doctors judge whether a MEK inhibitor is working in two main ways: by measuring the tumor on MRI scans and by asking how you\u2019re feeling, including your pain and how well you can move and function, says Giglio. Tumor Volume Plexiform neurofibromas are measured with volumetric MRI, which calculates a tumor\u2019s<\/p>\n","protected":false},"author":55,"featured_media":51267,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"categories":[97],"tags":[4180,36],"class_list":["post-51266","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-genetic-diseases","tag-mixtv"],"_links":{"self":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts\/51266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/comments?post=51266"}],"version-history":[{"count":0,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/posts\/51266\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/media\/51267"}],"wp:attachment":[{"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/media?parent=51266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/categories?post=51266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mixtv1.com\/index.php\/wp-json\/wp\/v2\/tags?post=51266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}